Lence Through Ethics Essay 2013

The leap from gene editing in ‘somatic’ cells (e.g.normal liver cells or pathogenic mutations in cancers) to performing it in ‘germ’ cells, may seem trivial, for the same laboratory procedures with CRISPR–Cas9 would be used.

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The valid claim of genetic exceptionalism supports restraint on experimentation in human germ cells, given the trans-generational dangers and the knowledge gap in germ cell biology.

Standing for ‘Clustered, Regularly Interspaced, Short Palindromic Repeats’ in association with the Cas9 DNA-cutting enzyme, the system in nature provides bacteria with immunity from viruses and phages, and silences genes that make molecular surface markers.

The avalanche of commentaries on CRISPR–Cas9 technology, a bacterial immune system modified to recognize any short DNA sequence, cut it out, and insert a new one, has rekindled hopes for gene therapy and other applications and raised criticisms of engineering genes in future generations.

CRISPR–Cas9 has taken the pace and prospects for genetic discovery and applications to a high level, stoking anticipation for somatic gene engineering to help patients. We place increased emphasis on the principle of solidarity and the public good.

Hence, we go further than the Summit to endorse a moratorium on experiments with CRISPR–Cas9 and related technologies aimed toward germ cell mutations.

Lence Through Ethics Essay 2013

Our ‘first’ controversy is that CRISPR–Cas9 requires a complex and nuanced debate of principles of clinical and research ethics beyond what the long established ones) , but which we use here to recognize the opportunities to share benefits as a public good; it helps conceptualize how disruptive technologies are also social phenomena that are subject to rapid and constant transformations.But, we agree with others that the step crosses an ethical Rubicon.The process of snipping out a deleterious mutation, inserting a ‘normal’ DNA sequence, and then zipping the DNA back up again sounds clinically advantageous, but that assumption belies the complexities of taking technologies from bench to bedside.After stating our methods, we group our views into four sections: areas of agreement, areas of controversy, growing points and areas timely for developing research.This is not a systemic review, but relies on our review of research, clinical, and popular media sources, aided by Pub Med and Google searches using the keywords ‘CRISPR AND ethics’ and other similar terms for the years 2014 to present (August 2016).In 2015, an International Summit on Human Gene Editing (hereafter, the Summit), sponsored by the (US) National Academy of Sciences and National Academy of Medicine, the Chinese Academy of Sciences, and the Royal Society of the UK, Soon, the Nuffield Council on Bioethics called for evidence on the ethical issues emerging from this ‘family of biological techniques for making precise genetic alterations to living cells’ that have applications in agricultural and livestock, industrial biotechnology, ecology, biomedicine and reproduction; and has recently published its findings.Here, we review the literature on these issues and present the position of the Committee on Ethics, Law and Society (CELS) of the Human Genome Organisation (HUGO) on CRISPR–Cas9, with our continuing emphasis on the neglected ethical principle of solidarity and the priority on public good.HUGO's CELS is a mechanism for HUGO to proactively initiate and facilitate dialogs on the ethical, legal and social issues related to genetics and genomics.The CELS undertakes projects to understand conceptual issues that underlie genomic sciences in practice and policy. We focus on CRISPR's applications in human biology and medicine, not at all to diminish its importance in other areas that also affect human beings.Other helpful websites were those of the Nuffield Council on Bioethics, This discussion expresses the consensus of HUGO's CELS.Our use of ‘we’ indicates the Committee members’ agreement and draws on our previous statements published by the Committee.


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